Mast Cell Activation Syndrome – An Underrecognised Cause of Chronic Disease
Mast cells (MCs) are specialised immune system cells that form part of the body’s initial defence system. When activated, they react to foreign bodies and injury by releasing a variety of chemical mediators such as histamine, prostaglandins, leukotrienes, cytokines and chemokines. In some people however, genetically altered MCs inappropriately release mediators which drive chronic multisystem inflammation and allergy.
Utilising Genetic Testing to Individualise Immune Prescribing
In the last year there has been a significant increase in public awareness around maintaining a strong immune system, and to a lesser extent, managing comorbidities that may influence the ability to deal with infection. While a patient’s environment and lifestyle choices can obviously drive the health of their immune system, 76% of immune traits have been associated with genetic influences.
Allergies and Autoimmunity – What is the Connection?
The long-term risk of developing an autoimmune disorder is significantly higher in patients with allergies, which may explain why the prevalence of both diseases is increasing in parallel. But why is it that Th2- and Th1-mediated autoimmune diseases can occur concurrently when, in theory, they should balance and even counteract each other?
This article explores recent evidence in allergy and autoimmunity, and discusses herbal medicines and nutritionals that help target underlying immune mechanisms.